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Article

Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells.

Nature communications - 4 Jan 2021

Ribeiro-Parenti Lara, Jarry Anne-Charlotte, Cavin Jean-Baptiste, Willemetz Alexandra, Le Beyec Johanne, Sannier Aurélie, Benadda Samira, Pelletier Anne-Laure, Hourseau Muriel, Léger Thibaut, Morlet Bastien, Couvelard Anne, Anini Younes, Msika Simon, Marmuse Jean-Pierre, Ledoux Sévérine, Le Gall Maude, Bado André

Abstract excerpt

Glucagon-Like Peptide-1 (GLP-1) undergoes rapid inactivation by dipeptidyl peptidase-4 (DPP4) suggesting that target receptors may be activated by locally produced GLP-1. Here we describe GLP-1 positive cells in the rat and human stomach and found these cells co-expressing ghrelin or somatostatin and able to secrete active GLP-1 in the rats. In lean rats, a gastric load of glucose induces a rapid and parallel...

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Identifiers

PMID: 33397977
DOI: 10.1038/s41467-020-20301-1
PMCID: PMC7782689

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