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Article

Modeling dysbiosis of human NASH in mice: Loss of gut microbiome diversity and overgrowth of Erysipelotrichales.

PloS one - 1 Jan 2021

Carter James K, Bhattacharya Dipankar, Borgerding Joshua N, Fiel M Isabel, Faith Jeremiah J, Friedman Scott L

Abstract excerpt

BACKGROUND & AIM: Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease (NAFLD) that is responsible for a growing fraction of cirrhosis and liver cancer cases worldwide. Changes in the gut microbiome have been implicated in NASH pathogenesis, but the lack of suitable murine models has been a barrier to progress. We have therefore characterized the microbiome in a...

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Identifiers

PMID: 33395434
DOI: 10.1371/journal.pone.0244763
PMCID: PMC7781477

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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