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Article

Pyrimethamine-based targeting of HEXA gene mutations in Tay-Sachs disease: a computational analysis.

Journal of biomolecular structure & dynamics - 1 Aug 2026

Ranjani S, Kumar N Sidharth, Madhana Priya N, Ahmed Shiek S S J, Magesh R

Abstract excerpt

Hexosaminidase-Tay Sachs disease (TSD) is a fatal, progressive neurodegenerative disorder, brought on by an accumulation of GM2 gangliosides that results from a deficiency. Treatment requires the restoration of the brain's HEXA enzyme, but the blood-brain barrier makes this difficult by preventing the preponderance of molecules from entering the brain. This study uses computational approaches analyzing the...

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Identifiers

PMID: 41719140
DOI: 10.1080/07391102.2026.2632159

Genes

HEXA
PC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Pyrimethamine-based targeting of HEXA gene mutations in Tay-Sachs disease: a computational analysisPMID 41719140Read ↗

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