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Evolution and Medical Significance of LU Domain−Containing Proteins

5 Jun 2019

Abstract excerpt

Proteins containing Ly6/uPAR (LU) domains exhibit very diverse biological functions and have broad taxonomic distributions in eukaryotes. In general, they adopt a characteristic three-fingered folding topology with three long loops projecting from a disulfide-rich globular core. The majority of the members of this protein domain family contain only a single LU domain, which can be secreted, glycolipid anchored,...

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PMID: 31195646
DOI: 10.3390/ijms20112760

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