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Article

HLA-E typing of more than 2.5 million potential hematopoietic stem cell donors: Methods and population-specific allele frequencies.

Human immunology - 1 Jul 2021

Sauter J, Putke K, Schefzyk D, Pruschke J, Solloch U V, Bernas S N, Massalski C, Daniel K, Klussmeier A, Hofmann J A, Lange V, Schmidt A H

Abstract excerpt

We developed a cost-efficient workflow for genotyping HLA-E by NGS and applied it for genotyping more than 2.5 million potential stem cell donors. The data obtained were used to determine HLA-E allele frequency distributions for 104 populations. Our results confirm the known dominance of the alleles E*01:01 and E*01:03, which have a combined frequency of more than 0.99 in 97 of the 104 populations. E*01:01 is...

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Identifiers

PMID: 33386168
DOI: 10.1016/j.humimm.2020.12.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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