Article
RAINFOREST: a random forest approach to predict treatment benefit in data from (failed) clinical drug trials.
Bioinformatics (Oxford, England) - 30 Dec 2020
Ubels Joske, Schaefers Tilman, Punt Cornelis, Guchelaar Henk-Jan, de Ridder Jeroen
Abstract excerpt
MOTIVATION: When phase III clinical drug trials fail their endpoint, enormous resources are wasted. Moreover, even if a clinical trial demonstrates a significant benefit, the observed effects are often small and may not outweigh the side effects of the drug. Therefore, there is a great clinical need for methods to identify genetic markers that can identify subgroups of patients which are likely to benefit from...
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