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Article

Quality-Control Mechanism for Telomerase RNA Folding in the Cell.

Cell reports - 29 Dec 2020

Hu Xichan, Kim Jin-Kwang, Yu Clinton, Jun Hyun-Ik, Liu Jinqiang, Sankaran Banumathi, Huang Lan, Qiao Feng

Abstract excerpt

Long non-coding RNAs can often fold into different conformations. Telomerase RNA, an essential component of the telomerase ribonucleoprotein (RNP) enzyme, must fold into a defined structure to fulfill its function with the protein catalytic subunit (TERT) and other accessory factors. However, the mechanism by which the correct folding of telomerase RNA is warranted in a cell is still unknown. Here we show that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33378677
DOI: 10.1016/j.celrep.2020.108568

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