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Article

Functional characterization of ATF1, GREM2 AND WNT10B variants associated with tooth agenesis.

Orthodontics & craniofacial research - 1 Nov 2021

Williams Meredith, Zeng Yu, Chiquet Brett, Jacob Helder, Kurtis Kasper Fred, Harrington Daniel A, English Jeryl, Akyalcin Sercan, Letra Ariadne

Abstract excerpt

OBJECTIVE: To determine the functional effects of ATF1, WNT10B and GREM2 gene variants identified in individuals with tooth agenesis (TA). SETTINGS AND SAMPLE POPULATION: Stem cells from human exfoliated deciduous teeth (SHED) were used as an in vitro model system to test the effect of TA-associated variants. MATERIALS AND METHODS: Plasmid constructs containing reference and mutant alleles for ATF1 rs11169552,...

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PMID: 33369218
DOI: 10.1111/ocr.12462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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