Comparative genomics revealed adaptive admixture in Cryptosporidium hominis in Africa.

doi:10.1099/mgen.0.000493

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Comparative genomics revealed adaptive admixture in Cryptosporidium hominis in Africa.

Microbial genomics - 1 Jan 2021

Tichkule Swapnil, Jex Aaron R, van Oosterhout Cock, Sannella Anna Rosa, Krumkamp Ralf, Aldrich Cassandra, Maiga-Ascofare Oumou, Dekker Denise, Lamshöft Maike, Mbwana Joyce, Rakotozandrindrainy Njari, Borrmann Steffen, Thye Thorsten, Schuldt Kathrin, Winter Doris, Kremsner Peter G, Oppong Kwabena, Manouana Prince, Mbong Mirabeau, Gesase Samwel, Minja Daniel T R, Mueller Ivo, Bahlo Melanie, Nader Johanna, May Jürgen, Rakotozandrindrain Raphael, Adegnika Ayola Akim, Lusingu John P A, Amuasi John, Eibach Daniel, Caccio Simone Mario

Abstract excerpt

Cryptosporidiosis is a major cause of diarrhoeal illness among African children, and is associated with childhood mortality, malnutrition, cognitive development and growth retardation. Cryptosporidium hominis is the dominant pathogen in Africa, and genotyping at the glycoprotein 60 (gp60) gene has revealed a complex distribution of different subtypes across this continent. However, a comprehensive exploration of...

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PMID: 33355530
DOI: 10.1099/mgen.0.000493
PMCID: PMC8115899

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