Article
HCV-Associated Exosomes Upregulate RUNXOR and RUNX1 Expressions to Promote MDSC Expansion and Suppressive Functions through STAT3-miR124 Axis.
Cells - 18 Dec 2020
Thakuri Bal Krishna Chand, Zhang Jinyu, Zhao Juan, Nguyen Lam N, Nguyen Lam N T, Schank Madison, Khanal Sushant, Dang Xindi, Cao Dechao, Lu Zeyuan, Wu Xiao Y, Jiang Yong, El Gazzar Mohamed, Ning Shunbin, Wang Ling, Moorman Jonathan P, Yao Zhi Q
Abstract excerpt
RUNX1 overlapping RNA (RUNXOR) is a long non-coding RNA and plays a pivotal role in the differentiation of myeloid cells via targeting runt-related transcription factor 1 (RUNX1). We and others have previously reported that myeloid-derived suppressor cells (MDSCs) expand and inhibit host immune responses during chronic viral infections; however, the mechanisms responsible for MDSC differentiation and suppressive...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.