Article
IFN-α-based treatment of patients with chronic HCV show increased levels of cells with myeloid-derived suppressor cell phenotype and of IDO and NOS.
Immunopharmacology and immunotoxicology - 1 Aug 2017
Salem Mohamed Labib, Zidan Abdel-Aziz A, Attia Mohamed, El-Naggar Randa E, Nassef Mohamed, Abou El-Azm Abdel Raouf, El-Bate Hasan, Yussif Mohamed, Galal Sohaila, Abo Senna Mohamed, El Demellawy Maha
Abstract excerpt
INTRODUCTION: Hepatitis C virus (HCV) infection causes chronic hepatitis, which is often associated with suppressed anti-HCV immune responses. We have recently reported accumulation of myeloid-derived suppressor cells (MDSCs) and suppressed immunity in cancer patients. AIM: The main aim of this study was to determine whether chronic HCV patients harbor high of MDSCs in general and in nonresponders to IFN-based...
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