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Article

Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons

18 Dec 2020

Abstract excerpt

BACKGROUND: The chromosome 22q11.2 deletion is an extremely high risk genetic factor for various neuropsychiatric disorders; however, the 22q11.2 deletion-related brain pathology in humans at the cellular and molecular levels remains unclear. METHODS: We generated iPS cells from healthy controls (control group) and patients with 22q11.2 deletion (22DS group), and differentiated them into dopaminergic neurons....

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PMID: 33341442
DOI: 10.1016/j.ebiom.2020.103138

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