Article
Generating adverse outcome pathway (AOP) of inorganic arsenic-induced adult male reproductive impairment via integration of phenotypic analysis in comparative toxicogenomics database (CTD) and AOP wiki.
Toxicology and applied pharmacology - 15 Jan 2021
Chai Zili, Zhao Chenhao, Jin Yuan, Wang Yimeng, Zou Peng, Ling Xi, Yang Huan, Zhou Niya, Chen Qing, Sun Lei, Chen Wen, Ao Lin, Cao Jia, Liu Jinyi
Abstract excerpt
BACKGROUND: Inorganic arsenic (iAs) is a worldwide environmental pollutant which exerts complicated and various toxic effects in organisms. Increasingly epidemic studies have revealed the association between iAs exposure and adult male reproductive impairment. Consistent with the proposal for toxicity testing in the 21st century (TT21C), the adverse outcome pathway (AOP) framework may help unravel the iAs-caused...
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