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Article

Genetic Factors in Antiphospholipid Syndrome: Preliminary Experience with Whole Exome Sequencing.

International journal of molecular sciences - 15 Dec 2020

Barinotti Alice, Radin Massimo, Cecchi Irene, Foddai Silvia Grazietta, Rubini Elena, Roccatello Dario, Sciascia Savino, Menegatti Elisa

Abstract excerpt

As in many autoimmune diseases, the pathogenesis of the antiphospholipid syndrome (APS) is the result of a complex interplay between predisposing genes and triggering environmental factors, leading to a loss of self-tolerance and immune-mediated tissue damage. While the first genetic studies in APS focused primarily on the human leukocytes antigen system (HLA) region, more recent data highlighted the role of...

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Identifiers

PMID: 33333988
DOI: 10.3390/ijms21249551
PMCID: PMC7765384

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