Bidirectional Causal Associations Between Inflammatory Bowel Disease and Ankylosing Spondylitis: A Two-Sample Mendelian Randomization Analysis

Abstract excerpt

Background: Associations between inflammatory bowel disease (IBD) (including ulcerative colitis (UC) and Crohn’s disease (CD)) and ankylosing spondylitis (AS) were discovered in observational studies, but no evidence supported the causal relationship between the two diseases. Methods: We employed two-sample Mendelian randomization (MR) to estimate the unconfounded bidirectional causal associations between IBD...

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