Article
Suppressor Mutations in Type II Secretion Mutants of Vibrio cholerae: Inactivation of the VesC Protease.
mSphere - 16 Dec 2020
Rule Chelsea S, Park Young-Jun, Delarosa Jaclyn R, Turley Stewart, Hol Wim G J, McColm Sarah, Gura Colby, DiMaio Frank, Korotkov Konstantin V, Sandkvist Maria
Abstract excerpt
The type II secretion system (T2SS) is a conserved transport pathway responsible for the secretion of a range of virulence factors by many pathogens, including Vibrio cholerae Disruption of the T2SS genes in V. cholerae results in loss of secretion, changes in cell envelope function, and growth defects. While T2SS mutants are viable, high-throughput genomic analyses have listed these genes among essential genes....
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