Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elevated MCP-1 serum levels are associated with the H63D mutation and not the C282Y mutation in hereditary hemochromatosis.

Tissue antigens - 1 Oct 2007

Lawless M W, White M, Mankan A K, O'Dwyer M J, Norris S

Abstract excerpt

Monocyte chemoattractant protein-1 (MCP-1) is a major lymphocyte and inflammatory chemokine associated with persistent inflammatory states. Several abnormalities in the immune status of patients with hereditary hemochromatosis (HH) have been reported, suggesting an imbalance in their immune function. This may include persistent production of, or exposure to, inflammatory cytokines contributing to the pathogenesis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokine CCL2
Share to Ferritins
Share to Hemochromatosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemochromatosis Protein

Share to Histocompatibility Antigens Class I

Share to Homozygote

Share to Transferrin

Source

Identifiers

PMID: 17767550
DOI: 10.1111/j.1399-0039.2007.00895.x

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elevated MCP-1 serum levels are associated with the H63D mutation and not the C282Y mutation in hereditary hemochromatosis.PMID 17767550Read ↗

Cytokine and Gene Expression Profiling in Patients with HFE-Associated Hereditary Hemochromatosis according to Genetic Profile.Semantic proximity Read ↗

Influence of HFE variants and cellular iron on monocyte chemoattractant protein-1.Semantic proximity Read ↗

The clinical relevance of compound heterozygosity for the C282Y and H63D substitutions in hemochromatosis.Semantic proximity Read ↗

Highly sensitivity adhesion molecules detection in hereditary haemochromatosis patients reveals altered expression.Semantic proximity Read ↗

Individuals homozygous for the H63D mutation have significantly elevated iron indexes.Semantic proximity Read ↗

Variable phenotypic presentation of iron overload in H63D homozygotes: are genetic modifiers the cause?Semantic proximity Read ↗

The role of HFE genotype in macrophage phenotype.Semantic proximity Read ↗

HFE cross-talks with the MHC class I antigen presentation pathwaySemantic proximity Read ↗

Clinical and genetic heterogeneity in hereditary haemochromatosis: association between lymphocyte counts and expression of iron overload.Semantic proximity Read ↗

Major histocompatibility complex class I associations in iron overload: evidence for a new link between the HFE H63D mutation, HLA-A29, and non-classical forms of hemochromatosis.Semantic proximity Read ↗

Haptoglobin Genotype-Dependent Anti-Inflammatory Signaling in CD163+MacrophagesSemantic proximity Read ↗

Chronic inflammation does not appear to modify the homozygous hereditary hemochromatosis phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.