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Immune profile of the tumor microenvironment and the identification of a four-gene signature for lung adenocarcinoma

9 Dec 2020

Abstract excerpt

The composition and relative abundances of immune cells in the tumor microenvironment are key factors affecting the progression of lung adenocarcinomas (LUADs) and the efficacy of immunotherapy. Using the cancer gene expression dataset from The Cancer Genome Atlas (TCGA) program, we scored stromal and immune cells for tumor purity prediction by CIBERSORT and ESTMATE. Differential expression analysis was employed...

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PMID: 33318300
DOI: 10.18632/aging.202269

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