Article
Overexpression of chloride importer NKCC1 contributes to the sensory-affective and sociability phenotype of rats following neonatal maternal separation.
Brain, behavior, and immunity - 1 Feb 2021
Gazzo Géraldine, Melchior Meggane, Caussaint Andréa, Gieré Clémence, Lelièvre Vincent, Poisbeau Pierrick
Abstract excerpt
BACKGROUND: Early life stress is known to affect the development of the nervous system and its function at a later age. It increases the risk to develop psychiatric disorders as well as chronic pain and its associated affective comorbidities across the lifespan. GABAergic inhibition is important for the regulation of central function and related behaviors, including nociception, anxiety or social interactions,...
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