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Article

Farnesoid X Receptor Activation Impairs Liver Progenitor Cell-Mediated Liver Regeneration via the PTEN-PI3K-AKT-mTOR Axis in Zebrafish.

Hepatology (Baltimore, Md.) - 1 Jul 2021

Jung Kyounghwa, Kim Minwook, So Juhoon, Lee Seung-Hoon, Ko Sungjin, Shin Donghun

Abstract excerpt

BACKGROUND AND AIMS: Following mild liver injury, pre-existing hepatocytes replicate. However, if hepatocyte proliferation is compromised, such as in chronic liver diseases, biliary epithelial cells (BECs) contribute to hepatocytes through liver progenitor cells (LPCs), thereby restoring hepatic mass and function. Recently, augmenting innate BEC-driven liver regeneration has garnered attention as an alternative...

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Source

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Identifiers

PMID: 33314176
DOI: 10.1002/hep.31679
PMCID: PMC8605479

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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