Article
HLA association with the susceptibility to anti-synthetase syndrome.
Joint bone spine - 1 May 2021
Remuzgo-Martínez Sara, Atienza-Mateo Belén, Ocejo-Vinyals J Gonzalo, Pulito-Cueto Verónica, Prieto-Peña Diana, Genre Fernanda, Marquez Ana, Llorca Javier, Mora Cuesta Víctor M, Fernández David Iturbe, Riesco Laura, Ortego-Centeno Norberto, Gómez Nair Pérez, Mera Antonio, Martínez-Barrio Julia, López-Longo Francisco Javier, Lera-Gómez Leticia, Moriano Clara, Díez Elvira, Tomero Eva, Calvo-Alén Jaime, Romero-Bueno Fredeswinda, Sanchez-Pernaute Olga, Nuño Laura, Bonilla Gema, Grafia Ignacio, Prieto-González Sergio, Narvaez Javier, Trallero-Araguas Ernesto, Selva-O'Callaghan Albert, Gualillo Oreste, Martín Javier, Cavagna Lorenzo, Castañeda Santos, Cifrian José M, Renzoni Elisabetta A, López-Mejías Raquel, González-Gay Miguel A
Abstract excerpt
OBJECTIVE: To investigate the human leukocyte antigen (HLA) association with anti-synthetase syndrome (ASSD). METHODS: We conducted the largest immunogenetic HLA-DRB1 and HLA-B study to date in a homogeneous cohort of 168 Caucasian patients with ASSD and 486 ethnically matched healthy controls by sequencing-based-typing. RESULTS: A statistically significant increase of HLA-DRB1*03:01 and HLA-B*08:01 alleles in...
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