Article
Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.
Cancer research - 1 Apr 2006
Zeng Zhihong, Samudio Ismael J, Zhang Weiguo, Estrov Zeev, Pelicano Hélène, Harris David, Frolova Olga, Hail Numsen, Chen Wenjing, Kornblau Steven M, Huang Peng, Lu Yiling, Mills Gordon B, Andreeff Michael, Konopleva Marina
Abstract excerpt
Phosphoinositol-3-kinase (PI3K)/protein kinase B (AKT) and Fms-like tyrosine kinase 3 (FLT3) signaling are aberrantly activated in acute myelogenous leukemia (AML) cells. Constitutively activated AKT and FLT3 regulate leukemia cell survival and resistance to chemotherapy. In this study, we investigated the effects of the novel multiple kinase inhibitor KP372-1 on the survival of AML cell lines and primary AML...
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