Article
A simultaneous exploratory and quantitative amino acid and biogenic amine metabolic profiling platform for rapid disease phenotyping via UPLC-QToF-MS.
Talanta - 1 Feb 2021
Gray Nicola, Lawler Nathan G, Yang Rongchang, Morillon Aude-Claire, Gay Melvin C L, Bong Sze-How, Holmes Elaine, Nicholson Jeremy K, Whiley Luke
Abstract excerpt
Metabolic phenotyping using mass spectrometry (MS) is being applied to ever increasing sample numbers in clinical and epidemiology studies. High-throughput and robust methods are being developed for the accurate measurement of metabolites associated with disease. Traditionally, quantitative assays have utilized triple quadrupole (QQQ) MS based methods; however, the use of such focused methods removes the ability...
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