Article
Genetic determinants of clinical phenotype in hypertrophic cardiomyopathy.
BMC cardiovascular disorders - 9 Dec 2020
Velicki Lazar, Jakovljevic Djordje G, Preveden Andrej, Golubovic Miodrag, Bjelobrk Marija, Ilic Aleksandra, Stojsic Snezana, Barlocco Fausto, Tafelmeier Maria, Okwose Nduka, Tesic Milorad, Brennan Paul, Popovic Dejana, Ristic Arsen, MacGowan Guy A, Filipovic Nenad, Maier Lars S, Olivotto Iacopo
Abstract excerpt
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease that affects approximately one in 500 people. HCM is a recognized genetic disorder most often caused by mutations involving myosin-binding protein C (MYBPC3) and β-myosin heavy chain (MYH7) which are responsible for approximately three-quarters of the identified mutations. METHODS: As a part of the international...
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