Article
Circadian clock gene BMAL1 reduces urinary calcium oxalate stones formation by regulating NRF2/HO-1 pathway.
Life sciences - 15 Jan 2021
Wang Jiahao, Bai Yunjin, Yin Shan, Cui Jianwei, Zhang Yu, Wang Xiaoming, Zhang Facai, Li Hong, Tang Yin, Wang Jia
Abstract excerpt
Calcium oxalate stones are closely related to oxalate metabolism and oxidative stress injury. Normal metabolism homeostasis and tissue repair are often affected by the biological rhythm, which plays an indispensable role in maintaining the homeostasis of the organism. Nuclear factor erythroid 2-related factor/heme oxygenase-1 (NRF2/HO-1) is one pathway related to oxidative stress injury in human body. Normal...
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