Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.

doi:10.1016/j.cell.2020.11.020

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Article

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.

Cell - 7 Jan 2021

Volz Erik, Hill Verity, McCrone John T, Price Anna, Jorgensen David, O'Toole Áine, Southgate Joel, Johnson Robert, Jackson Ben, Nascimento Fabricia F, Rey Sara M, Nicholls Samuel M, Colquhoun Rachel M, da Silva Filipe Ana, Shepherd James, Pascall David J, Shah Rajiv, Jesudason Natasha, Li Kathy, Jarrett Ruth, Pacchiarini Nicole, Bull Matthew, Geidelberg Lily, Siveroni Igor, Goodfellow Ian, Loman Nicholas J, Pybus Oliver G, Robertson David L, Thomson Emma C, Rambaut Andrew, Connor Thomas R

Abstract excerpt

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants,...

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Identifiers

PMID: 33275900
DOI: 10.1016/j.cell.2020.11.020
PMCID: PMC7674007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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