Article
Differential Effects of Clinically Relevant N- versus C-Terminal Truncating CDKN1A Mutations on Cisplatin Sensitivity in Bladder Cancer.
Molecular cancer research : MCR - 1 Mar 2021
Sikder Rahmat K, Ellithi Moataz, Uzzo Robert N, Weader David J, Metz Alexander L, Behbahani Ali, McKenzie Erica R, El-Deiry Wafik S, Abbosh Philip H
Abstract excerpt
Muscle-invasive bladder cancer (MIBC) frequently harbors mutations in the CDKN1A gene, which encodes the tumor suppressor protein p21, with the majority of alterations truncating the peptide. The effect of these mutations is poorly understood. We hypothesized that after DNA-damaging events, cells deficient in p21 would be unable to halt the cell cycle and efficiently repair DNA damage, thus proceeding down the...
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