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Article

Pan-cancer identification of clinically relevant genomic subtypes using outcome-weighted integrative clustering.

Genome medicine - 3 Dec 2020

Arora Arshi, Olshen Adam B, Seshan Venkatraman E, Shen Ronglai

Abstract excerpt

BACKGROUND: Comprehensive molecular profiling has revealed somatic variations in cancer at genomic, epigenomic, transcriptomic, and proteomic levels. The accumulating data has shown clearly that molecular phenotypes of cancer are complex and influenced by a multitude of factors. Conventional unsupervised clustering applied to a large patient population is inevitably driven by the dominant variation from major...

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Identifiers

PMID: 33272320
DOI: 10.1186/s13073-020-00804-8
PMCID: PMC7716509

Genes

CDKN2A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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