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Article

Cancer of unknown primary with EGFR mutation successfully treated with targeted therapy directed by clinical next-generation sequencing: a case report.

BMC cancer - 2 Dec 2020

Mitani Yosuke, Kanai Masashi, Kou Tadayuki, Kataoka Shigeki, Doi Keitaro, Matsubara Junichi, Ohashi Shinya, Matsumoto Shigemi, Muto Manabu

Abstract excerpt

BACKGROUND: Cancer of unknown primary (CUP) is usually treated with nonselective and empirical chemotherapy; however, its prognosis is generally poor, with a median survival of less than a year. Thus, clinicians eagerly await the development of more effective treatment strategies. In recent years, advances in next-generation sequencing (NGS) have made it possible to analyze comprehensively the genome of...

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Identifiers

PMID: 33267781
DOI: 10.1186/s12885-020-07640-4
PMCID: PMC7709432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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