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Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids

27 Nov 2020

Abstract excerpt

Glioblastoma (GBM) is the most aggressive brain cancer and its relapse after surgery, chemo and radiotherapy appears to be led by GBM stem cells (GSCs). Also, tumor networking and intercellular communication play a major role in driving GBM therapy-resistance. Tunneling Nanotubes (TNTs), thin membranous open-ended channels connecting distant cells, have been observed in several types of cancer, where they emerge...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33245115
DOI: 10.1042/bcj20200710

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