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Gene Expression and Co-expression Networks Are Strongly Altered Through Stages in Clear Cell Renal Carcinoma

3 Nov 2020

Abstract excerpt

Clear cell renal carcinoma (ccRC) is a highly progressively malignant disease. Analyzing ccRC progression at the genetic level may give us a glimpse towards improved therapeutics. In this work, by using TCGA data, we studied the molecular progression of the four main ccRC stages (i, ii, iii, iv) in two different yet complementary approaches: a) gene expression and b) gene co-expression. For a) we analyzed the...

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PMID: 33240325
DOI: 10.3389/fgene.2020.578679

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