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Article

Generalized correlation coefficient for genome-wide association analysis of cognitive ability in twins.

Aging - 24 Nov 2020

Mohammadnejad Afsaneh, Nygaard Marianne, Li Shuxia, Zhang Dongfeng, Xu Chunsheng, Li Weilong, Lund Jesper, Christiansen Lene, Baumbach Jan, Christensen Kaare, Hjelmborg Jacob V B, Tan Qihua

Abstract excerpt

Despite a strong genetic background in cognitive function only a limited number of single nucleotide polymorphisms (SNPs) have been found in genome-wide association studies (GWASs). We hypothesize that this is partially due to mis-specified modeling concerning phenotype distribution as well as the relationship between SNP dosage and the level of the phenotype. To overcome these issues, we introduced an...

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PMID: 33232274
DOI: 10.18632/aging.104198
PMCID: PMC7746382

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