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Article

Pan-cancer methylation analysis reveals an inverse correlation of tumor immunogenicity with methylation aberrancy.

Cancer immunology, immunotherapy : CII - 1 Jun 2021

Park Changhee, Jeong Kyeonghun, Park Joon-Hyeong, Jung Sohee, Bae Jeong Mo, Kim Kwangsoo, Ock Chan-Young, Kim Miso, Keam Bhumsuk, Kim Tae Min, Jeon Yoon Kyung, Lee Se-Hoon, Lee Ju-Seog, Kim Dong-Wan, Kang Gyeong Hoon, Chung Doo Hyun, Heo Dae Seog

Abstract excerpt

Tumor immunogenicity is driven by various genomic and transcriptomic factors but the association with the overall status of methylation aberrancy is not well established. We analyzed The Cancer Genome Atlas pan-cancer database to investigate whether the overall methylation aberrancy links to the immune evasion of tumor. We created the definitions of hypermethylation burden, hypomethylation burden and methylation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33230567
DOI: 10.1007/s00262-020-02796-1
PMCID: PMC10992373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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