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Genetic Analysis of Prosaposin, the Lysosomal Storage Disorder Gene in Parkinson's Disease.

Molecular neurobiology - 1 Apr 2021

Chen Yong-Ping, Gu Xiao-Jing, Ou Ru-Wei, Zhang Ling-Yu, Hou Yan-Bing, Liu Kun-Cheng, Cao Bei, Wei Qian-Qian, Song Wei, Zhao Bi, Wu Ying, Cheng Jing-Qiu, Shang Hui-Fang

Abstract excerpt

Recent genetic studies clearly indicate that variants in several lysosomal genes act as risk factors for idiopathic Parkinson's disease (PD). Variants in the co-activator of glucocerebrosidase gene (GBA) and the four active saposins (Sap A-D) which are encoded by the prosaposin gene (PSAP) are of particular interest; however, their genetic roles in PD are unknown. Whole-exome sequencing and Sanger sequencing were...

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PMID: 33219486
DOI: 10.1007/s12035-020-02218-4

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