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Article

A streamlined proliferation assay using mixed lymphocytes for evaluation of human mesenchymal stem cell immunomodulation activity.

Journal of immunological methods - 1 Jan 2021

Herzig Maryanne C, Delavan Christopher P, Jensen Katherine J, Cantu Carolina, Montgomery Robbie K, Christy Barbara A, Cap Andrew P, Bynum James A

Abstract excerpt

BACKGROUND: Mesenchymal stromal cells (MSCs) have been proposed for treatment of acute respiratory distress syndrome (ARDS), graft versus host disease (GVHD), wound healing and trauma. A consensus is building that immunomodulation by MSCs is important for therapeutic potential. MSCs suppress peripheral blood mononuclear cell (PBMC) proliferation in vitro, potentially reflecting an ability to suppress PBMC...

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Identifiers

PMID: 33212091
DOI: 10.1016/j.jim.2020.112915

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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