Article
Comparisons of phenotype and immunomodulatory capacity among rhesus bone-marrow-derived mesenchymal stem/stromal cells, multipotent adult progenitor cells, and dermal fibroblasts.
Journal of medical primatology - 1 Aug 2014
Sindberg Gregory M, Lindborg Beth A, Wang Qi, Clarkson Christina, Graham Melanie, Donahue Robert, Hering Bernhard J, Verfaillie Catherine M, Bansal-Pakala Pratima, O'Brien Timothy D
Abstract excerpt
BACKGROUND: Potent immunomodulatory effects have been reported for mesenchymal stem/stromal cells (MSCs), multipotent adult progenitor cells (MAPCs), and fibroblasts. However, side-by-side comparisons of these cells specifically regarding immunophenotype, gene expression, and suppression of proliferation of CD4(+) and CD8(+) lymphocyte populations have not been reported. METHODS: We developed MAPC and MSC lines...
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