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Article

Monolithic hydrogel nanowells-in-microwells enabling simultaneous single cell secretion and phenotype analysis.

Lab on a chip - 15 Dec 2020

Choi Jane Ru, Lee Jeong Hyun, Xu Alec, Matthews Kerryn, Xie Shuyong, Duffy Simon P, Ma Hongshen

Abstract excerpt

Cytokine secretion is a form of cellular communication that regulates a wide range of biological processes. A common approach for measuring cytokine secretion from single cells is to confine individual cells in arrays of nanoliter wells (nanowells) fabricated using polydimethylsiloxane. However, this approach cannot be easily integrated in standard microwell plates in order to take advantage of high-throughput...

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PMID: 33201962
DOI: 10.1039/d0lc00965b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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