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Generation of an induced pluripotent stem cell line (HMSCATi004-A) from an early onset Parkinson's disease patient with PRKN gene mutation.

Stem cell research - 1 Dec 2024

Cheng Jingke, Zhai Yingtong, Guo Xiangge, Wang Xumeng, Ma Min, Ren Xin, Wang Shan, Cui Huixian, Ren Qian

Abstract excerpt

Parkin (PRKN) is recognized as causative gene in early-onset Parkinson's disease (PD). Induced pluripotent stem cells (iPSCs) were derived from a 29-year-old PD patient carrying a heterozygous c.823C > T (p.R275W) variant and an exon 2-4 deletion in PRKN. The Generated iPSCs maintain a normal karyotype, express pluripotency markers, and retain the ability to differentiate into the three germ layers. This iPSC...

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Identifiers

PMID: 39405989
DOI: 10.1016/j.scr.2024.103578

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Generation of an induced pluripotent stem cell line (HMSCATi004-A) from an early onset Parkinson's disease patient with PRKN gene mutation.PMID 39405989Read ↗

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