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Article

A novel peptide nucleic acid- and loop-mediated isothermal amplification assay for the detection of mutations in the 23S rRNA gene of Treponema pallidum.

Journal of medical microbiology - 1 Dec 2020

Tarumoto Norihito, Imai Kazuo, Nakayama Shu-Ichi, Itoda Ichiro, Sakai Jun, Murakami Takashi, Maesaki Shigefumi, Hayakawa Satoshi, Ohnishi Makoto, Maeda Takuya

Abstract excerpt

Introduction. Macrolides could be a potential alternative treatment for Treponema pallidum infections in patients; however, macrolide-resistant T. pallidum is spreading rapidly worldwide.Hypothesis/Gap Statement. There are presently no alternatives to serological tests for syphilis that can be used to evaluate therapeutic effects due to the fact that T. pallidum cannot be cultured in vitro.Aim. In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33180016
DOI: 10.1099/jmm.0.001275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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