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Article

LabWAS: Novel findings and study design recommendations from a meta-analysis of clinical labs in two independent biobanks.

PLoS genetics - 1 Nov 2020

Goldstein Jeffery A, Weinstock Joshua S, Bastarache Lisa A, Larach Daniel B, Fritsche Lars G, Schmidt Ellen M, Brummett Chad M, Kheterpal Sachin, Abecasis Goncalo R, Denny Joshua C, Zawistowski Matthew

Abstract excerpt

Phenotypes extracted from Electronic Health Records (EHRs) are increasingly prevalent in genetic studies. EHRs contain hundreds of distinct clinical laboratory test results, providing a trove of health data beyond diagnoses. Such lab data is complex and lacks a ubiquitous coding scheme, making it more challenging than diagnosis data. Here we describe the first large-scale cross-health system genome-wide...

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PMID: 33175840
DOI: 10.1371/journal.pgen.1009077
PMCID: PMC7682892

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