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Article

Targeting miR-10a-5p/IL-6R axis for reducing IL-6-induced cartilage cell ferroptosis

6 Nov 2020

Abstract excerpt

BACKGROUND: Intervertebral disc degeneration (IDD) causes lower back pain, and is often accompanied with robust inflammation. However, whether inflammation plays a role in IDD remains controversial, and the mechanism is ill-elucidated. METHODS: Cartilage specimens from patients with scoliosis (control) and IDD were examined for IL-6 and its receptor expression by qPCR and western blot. Primary human articular...

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PMID: 33166496
DOI: 10.1016/j.yexmp.2020.104570

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