EphB6 regulates social behavior through gut microbiota-mediated vitamin B6 metabolism and excitation/inhibition balance of medial prefrontal cortex in mice

Abstract excerpt

Autism spectrum disorder (ASD) is a developmental disorder with no effective pharmacological treatments so far. Gut microbiota has been suggested to contribute to autistic symptoms. However, the key genes and the mechanisms linking gut microbiota and brain dysfunctions in ASD are still unclear. Here, we found deletion of EphB6, an ASD-associated candidate gene, induced dysregulated gut microbiota and autism-like b...

Topics

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• Attention Deficit Hyperactivity Disorder
• Autism Spectrum Disorder Research
• Child Nutrition and Feeding Issues
• Child Nutrition and Water Access
• Clostridium difficile and Clostridium perfringens research
• Gut microbiota and health
• Infant Health and Development
• Probiotics and Fermented Foods

Identifiers and source

Literature Corpus work

626e08bf-ea4d-547e-a0d1-4225c53e9f6c

DOI

10.1101/787622