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Article

Contaminating DNA in human saliva alters the detection of variants from whole genome sequencing.

Scientific reports - 6 Nov 2020

Samson C A, Whitford W, Snell R G, Jacobsen J C, Lehnert K

Abstract excerpt

Cells obtained from human saliva are commonly used as an alternative DNA source when blood is difficult or less convenient to collect. Although DNA extracted from saliva is considered to be of comparable quality to that derived from blood, recent studies have shown that non-human contaminating DNA derived from saliva can confound whole genome sequencing results. The most concerning complication is that non-human...

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Share to Genome, Human
Share to Genomics and Phylogenetic Studies
Share to Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Saliva

Share to Salivary Gland Disorders and Functions

Share to Salivary Gland Tumors Diagnosis and Treatment

Share to Whole Genome Sequencing

Source

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Identifiers

PMID: 33159102
DOI: 10.1038/s41598-020-76022-4
PMCID: PMC7648094

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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