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Article

Evaluation of saliva as a source of accurate whole-genome and microbiome sequencing data.

Genetic epidemiology - 1 Jul 2021

Herzig Anthony F, Velo-Suárez Lourdes, Le Folgoc Gaëlle, Boland Anne, Blanché Hélène, Olaso Robert, Le Roux Liana, Delmas Christelle, Goldberg Marcel, Zins Marie, Lethimonnier Franck, Deleuze Jean-François, Génin Emmanuelle

Abstract excerpt

This study sets out to establish the suitability of saliva-based whole-genome sequencing (WGS) through a comparison against blood-based WGS. To fully appraise the observed differences, we developed a novel technique of pseudo-replication. We also investigated the potential of characterizing individual salivary microbiomes from non-human DNA fragments found in saliva. We observed that the majority of discordant...

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Identifiers

PMID: 33998042
DOI: 10.1002/gepi.22386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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