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Article

Autofluorescence-based sorting removes senescent cells from mesenchymal stromal cell cultures.

Scientific reports - 5 Nov 2020

Bertolo Alessandro, Guerrero Julien, Stoyanov Jivko

Abstract excerpt

Mesenchymal stromal cells (MSC) are used in cell therapy, but results depend on the unknown quality of cell populations. Extended culture time of MSC increases their senescent levels, leading to a critical loss of cell fitness. Here, we tested the suitability of MSC-sorting based on their FACS autofluorescence profile, for a rapid and non-invasive method of senescent cell elimination. Cells were classified in...

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Identifiers

PMID: 33154552
DOI: 10.1038/s41598-020-76202-2
PMCID: PMC7645702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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