Development of a Quantitative Multiplex PCR to Detect Three Common Alpha Thalassemia Deletions.

doi:10.1080/03630269.2023.2260744

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Article

Development of a Quantitative Multiplex PCR to Detect Three Common Alpha Thalassemia Deletions.

Hemoglobin - 1 Nov 2023

Hajimohammadi Zahra, Alimohammadi-Bidhendi Sara, Bagheri Amiri Fahimeh, Karimipoor Morteza, Davoudi-Dehaghani Elham, Entezam Mona

Abstract excerpt

Alpha thalassemia is an autosomal recessive genetic disorder with a high prevalence in the Middle East. The severe form of alpha-thalassemia is incompatible with life and can cause significant obstetric complications in the mother. Therefore, it is important to determine the genotype in parents who have a chance of having a fetus with one of the severe forms of this disease. A total of 112 samples that were...

Topics

Humans
Multiplex Polymerase Chain Reaction
alpha-Thalassemia
Genotype
Multigene Family
alpha-Globins

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Open in PubMed

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PMID: 37766586
DOI: 10.1080/03630269.2023.2260744

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