Article
Establishment and characterisation of testicular cancer patient-derived xenograft models for preclinical evaluation of novel therapeutic strategies.
Scientific reports - 3 Nov 2020
de Vries Gerda, Rosas-Plaza Ximena, Meersma Gert Jan, Leeuwenburgh Vincent C, Kok Klaas, Suurmeijer Albert J H, van Vugt Marcel A T M, Gietema Jourik A, de Jong Steven
Abstract excerpt
Testicular cancer (TC) is the most common solid tumour in young men. While cisplatin-based chemotherapy is highly effective in TC patients, chemoresistance still accounts for 10% of disease-related deaths. Pre-clinical models that faithfully reflect patient tumours are needed to assist in target discovery and drug development. Tumour pieces from eight TC patients were subcutaneously implanted in NOD scid gamma...
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