MDM2 gene amplification as selection tool for innovative targeted approaches in PD-L1 positive or negative muscle-invasive urothelial bladder carcinoma.

doi:10.1136/jclinpath-2020-207089

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Article

MDM2 gene amplification as selection tool for innovative targeted approaches in PD-L1 positive or negative muscle-invasive urothelial bladder carcinoma.

Journal of clinical pathology - 1 Jan 2022

Brunelli Matteo, Tafuri Alessandro, Cima Luca, Cerruto Maria Angela, Milella Michele, Zivi Andrea, Buti Sebastiano, Bersanelli Melissa, Fornarini Giuseppe, Vellone Valerio Gaetano, Rebuzzi Sara Elena, Procopio Giuseppe, Verzoni Elena, Bracarda Sergio, Sabbatini Roberto, Baldessari Cinzia, Eccher Albino, Passalacqua Rodolfo, Perrucci Bruno, Giganti Maria Olga, Donini Maddalena, Panni Stefano, Tucci Marcello, Prati Veronica, Ortega Cinzia, Caliò Anna, Alongi Filippo, Munari Enrico, Pappagallo Giovanni, Iacovelli Roberto, Mosca Alessandra, Porta Camillo, Martignoni Guido, Antonelli Alessandro

Abstract excerpt

AIMS: According to The Cancer Genome Atlas (TCGA), around 9% of bladder carcinomas usually show abnormalities of the murine double minute 2 (MDM2) gene, but a few studies have been investigated them. We profiled MDM2 gene amplification in a series of urothelial carcinomas (UC) considering the molecular subtypes and expression of programmed death ligand 1 (PD-L1). METHODS: 117 patients with muscle-invasive UC...

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PMID: 33144356
DOI: 10.1136/jclinpath-2020-207089

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Source receipt: pubmed, retrieved 6 Sept 2026.

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