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Andrographolide and Its 14-Aryloxy Analogues Inhibit Zika and Dengue Virus Infection

30 Oct 2020

Abstract excerpt

Andrographolide is a labdene diterpenoid with potential applications against a number of viruses, including the mosquito-transmitted dengue virus (DENV). In this study, we evaluated the anti-viral activity of three 14-aryloxy analogues (ZAD-1 to ZAD-3) of andrographolide against Zika virus (ZIKV) and DENV. Interestingly, one analogue, ZAD-1, showed better activity against both ZIKV and DENV than the parental...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33143016
DOI: 10.3390/molecules25215037

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