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Article

A novel substitution in NS5A enhances the resistance of hepatitis C virus genotype 3 to daclatasvir.

The Journal of general virology - 1 Jan 2021

Fernandes Campos Guilherme Rodrigues, Ward Joseph, Chen Shucheng, Bittar Cintia, Vilela Rodrigues João Paulo, Martinelli Ana de Lourdes Candolo, Souza Fernanda Fernandes, Pereira Leonardo Régis Leira, Rahal Paula, Harris Mark

Abstract excerpt

Hepatitis C virus (HCV) genotype 3 presents a high level of both baseline and acquired resistance to direct-acting antivirals (DAAs), particularly those targeting the NS5A protein. To understand this resistance we studied a cohort of Brazilian patients treated with the NS5A DAA, daclatasvir and the nucleoside analogue, sofosbuvir. We observed a novel substitution at NS5A amino acid residue 98 [serine to glycine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33141008
DOI: 10.1099/jgv.0.001496
PMCID: PMC8116786

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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